Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 12/20 | 0.36 |
| ▸ | PPARD | Q03181 | 12/20 | 0.36 |
| ▸ | PPARA | Q07869 | 12/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2316110 | 0.90 | PPARG (0.35) | PPARGPPARDPPARAMAPK14 | |
| SCHEMBL2317760 | 0.88 | MAPK14 (0.34) | PPARGPPARDPPARAMAPK14 | |
| SCHEMBL2316585 | 0.87 | BRAF (0.35) | MAPK14BRAFMAPK3MAPK1HCRTR2 | |
| SCHEMBL2364645 | 0.87 | MAPK14 (0.35) | PPARGPPARDPPARAMAPK14BRAF | |
| SCHEMBL17836539 | 0.87 | MAPK14 (0.34) | PPARGPPARDPPARAMAPK14 | |
| SCHEMBL2313322 | 0.85 | MAPK14 (0.35) | PPARGPPARDPPARAMAPK14BRAF | |
| SCHEMBL14108523 | 0.85 | MAPK14 (0.35) | PPARGPPARDPPARAMAPK14BRAF | |
| SCHEMBL17836529 | 0.85 | PPARG (0.35) | PPARGPPARDPPARAMAPK14 | |
| SCHEMBL2358799 | 0.85 | MAPK14 (0.39) | PPARGPPARDPPARAMAPK14BRAF | |
| SCHEMBL17836523 | 0.84 | BRAF (0.34) | MAPK14BRAFMAPK3MAPK1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2528909-A1 | SULFONAMIDO DERIVATIVES OF 3,4-DIARYLPYRAZOLES AS PROTEIN KINASE INHIBITORS | Nerviano Medical Sciences S.r.l. (IT) | 2012-12-05 | — | — | EP | disclosed |
| WO-2011092088-A1 | SULFONAMIDO DERIVATIVES OF 3,4-DIARYLPYRAZOLES AS PROTEIN KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-08-04 | — | — | WO | disclosed |