Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Pyridoxine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.83 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.83 |
| ▸ | HPGD | P15428 | 4/20 | 0.83 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.83 |
| ▸ | LMNA | P02545 | 4/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.54 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.53 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.53 |
| ▸ | PDXK | O00764 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 3/20 | 0.44 |
| ▸ | CA2 | P00918 | 3/20 | 0.44 |
| ▸ | CA9 | Q16790 | 3/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyridoxine SCHEMBL405402 | 1.00 | KDM4E (0.83) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| Pyridoxine SCHEMBL15486045 | 0.98 | KDM4E (0.80) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| Pyridoxine SCHEMBL9168156 | 0.98 | KDM4E (0.80) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| Pyridoxine SCHEMBL5346680 | 0.92 | KDM4E (0.80) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| Pyridoxine SCHEMBL30267871 | 0.91 | HPGD (1.00) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| Pyridoxine SCHEMBL30877002 | 0.91 | HPGD (1.00) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| Pyridoxine SCHEMBL3506 | 0.91 | HPGD (1.00) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| Pyridoxine SCHEMBL2322958 | 0.91 | HPGD (1.00) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| Pyridoxine SCHEMBL31514964 | 0.90 | KDM4E (0.77) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| Pyridoxine SCHEMBL4576970 | 0.90 | KDM4E (0.77) | KDM4EALDH1A1HPGDHSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230000807-A1 | CBD ORAL FORMULATION | CLEAR LAKE RESEARCH, LLC | 2023-01-05 | — | — | US | claimed |
| WO-2021146735-A1 | CBD ORAL FORMULATION | CLEAR LAKE RESEARCH, LLC (US) | 2021-07-22 | — | — | WO | claimed |
| US-20230149303-A1 | BUCCAL AND ENTERIC DELIVERY OF FATTY ACIDS IN FOODS AND BEVERAGES | CLEAR LAKE RESEARCH, LLC | 2023-05-18 | — | — | US | disclosed |
| US-20230000807-A1 | CBD ORAL FORMULATION | CLEAR LAKE RESEARCH, LLC | 2023-01-05 | — | — | US | disclosed |
| US-20230000807-A1 | CBD ORAL FORMULATION | CLEAR LAKE RESEARCH, LLC | 2023-01-05 | — | — | US | disclosed |
| WO-2021178465-A1 | BUCCAL AND ENTERIC DELIVERY OF FATTY ACIDS WITH ORAL HYGIENE PRACTICES | CLEAR LAKE RESEARCH, LLC (US) | 2021-09-10 | — | — | WO | disclosed |
| WO-2021146735-A1 | CBD ORAL FORMULATION | CLEAR LAKE RESEARCH, LLC (US) | 2021-07-22 | — | — | WO | disclosed |
| WO-2021146735-A1 | CBD ORAL FORMULATION | CLEAR LAKE RESEARCH, LLC (US) | 2021-07-22 | — | — | WO | disclosed |