Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2306100 | 0.78 | MAOB (0.41) | MAOBSLC6A2SLC6A3KDM4CMEN1 | |
| SCHEMBL12470014 | 0.76 | MAOB (0.41) | MAPTHTR1AMAOBKDM4CMEN1 | |
| SCHEMBL2303930 | 0.73 | MAOB (0.41) | MAPTMAPK1TDP1MAOBKMT2A | |
| SCHEMBL15312918 | 0.71 | MAOB (0.45) | TDP1L3MBTL1ADRA1AMAOBKMT2A | |
| SCHEMBL384667 | 0.68 | EDNRB (0.34) | MAPTMAPK1MEN1KMT2AALDH1A1 | |
| SCHEMBL6356278 | 0.64 | MAPT (0.60) | MAPTMAPK1TDP1L3MBTL1HTR1A | |
| SCHEMBL130119 | 0.63 | APP (0.72) | MAPTMAPK1TDP1L3MBTL1HTR1A | |
| SCHEMBL1121687 | 0.63 | MAPT (0.55) | MAPTMAPK1TDP1L3MBTL1HTR1A | |
| SCHEMBL5674481 | 0.63 | MAPT (0.76) | MAPTMAPK1TDP1L3MBTL1HTR1A | |
| SCHEMBL11974258 | 0.62 | MAPK1 (0.54) | MAPTMAPK1TDP1L3MBTL1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2350090-A2 | SPIRO-OXINDOLE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | Xenon Pharmaceuticals Inc. (CA) | 2011-08-03 | — | — | EP | disclosed |