Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 19/20 | 0.69 |
| ▸ | PDE2A | O00408 | 1/20 | 0.48 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2223555 | 1.00 | CHRM1 (0.69) | CHRM1PDE2APDE11A | |
| SCHEMBL12803357 | 0.94 | CHRM1 (0.69) | CHRM1 | |
| SCHEMBL2222661 | 0.91 | CHRM1 (0.57) | CHRM1PDE2APDE11A | |
| SCHEMBL2225587 | 0.91 | CHRM1 (0.57) | CHRM1PDE2APDE11A | |
| SCHEMBL17585466 | 0.91 | CHRM1 (0.60) | CHRM1PDE2APDE11A | |
| SCHEMBL2224239 | 0.91 | CHRM1 (0.56) | CHRM1PDE2APDE11A | |
| SCHEMBL2272502 | 0.90 | CHRM1 (0.66) | CHRM1PDE2APDE11A | |
| SCHEMBL2222427 | 0.90 | CHRM1 (0.63) | CHRM1PDE2APDE11A | |
| SCHEMBL2223144 | 0.90 | CHRM1 (0.63) | CHRM1PDE2APDE11A | |
| SCHEMBL12803022 | 0.89 | CHRM1 (0.55) | CHRM1PDE2APDE11A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9199939-B2 | Quinoline amide M1 receptor positive allosteric modulators | MERCK SHARP & DOHME CORP. (US) | 2015-12-01 | — | — | US | claimed |
| EP-2512243-A1 | QUINOLINE AMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | Merck Sharp & Dohme Corp. (US) | 2012-10-24 | — | — | EP | claimed |
| WO-2011084368-A1 | QUINOLINE AMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-14 | — | — | WO | claimed |