Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSA | P10619 | 17/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.64 |
| ▸ | MME | P08473 | 2/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2364942 | 1.00 | CTSA (0.64) | CTSACYP3A4MMEPTGS2NPSR1 | |
| SCHEMBL2364991 | 1.00 | CTSA (0.64) | CTSACYP3A4MMEPTGS2NPSR1 | |
| SCHEMBL2365150 | 1.00 | CTSA (0.64) | CTSACYP3A4MMEPTGS2NPSR1 | |
| SCHEMBL2364857 | 0.93 | CTSA (0.63) | CTSACYP3A4MMEPTGS2 | |
| SCHEMBL2364622 | 0.93 | CTSA (0.63) | CTSACYP3A4MMEPTGS2 | |
| SCHEMBL15639920 | 0.93 | CTSA (0.63) | CTSACYP3A4MMEPTGS2 | |
| SCHEMBL2364621 | 0.93 | CTSA (0.63) | CTSACYP3A4MMEPTGS2 | |
| SCHEMBL14696355 | 0.93 | CTSA (0.59) | CTSACYP3A4MMEPTGS2 | |
| SCHEMBL14696628 | 0.93 | CTSA (0.59) | CTSACYP3A4MMEPTGS2 | |
| SCHEMBL14696357 | 0.93 | CTSA (0.59) | CTSACYP3A4MMEPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014053533-A1 | USE OF SUBSTITUTED 3-HETEROAROYLAMINO-PROPIONIC ACID DERIVATIVES AS PHARMACEUTICALS FOR PREVENTION/TREATMENT OF ATRIAL FIBRILLATION | SANOFI (FR) | 2014-04-10 | — | — | WO | disclosed |
| EP-2528902-A1 | OXYGEN-SUBSTITUTED 3-HETEROAROYLAMINO-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | SANOFI (FR) | 2012-12-05 | — | — | EP | disclosed |
| WO-2011092187-A1 | OXYGEN-SUBSTITUTED 3-HETEROAROYLAMINO-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | SANOFI (FR) | 2011-08-04 | — | — | WO | disclosed |