Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 19/20 | 0.44 |
| ▸ | JAK2 | O60674 | 10/20 | 0.43 |
| ▸ | JAK1 | P23458 | 9/20 | 0.43 |
| ▸ | TYK2 | P29597 | 4/20 | 0.42 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | MARK3 | P27448 | 2/20 | 0.39 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.39 |
| ▸ | STK3 | Q13188 | 2/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.39 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.39 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.39 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.39 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.39 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10080257 | 0.88 | JAK3 (0.53) | JAK3JAK2JAK1TYK2PKN2 | |
| SCHEMBL353135 | 0.88 | JAK3 (0.53) | JAK3JAK2JAK1TYK2PKN2 | |
| SCHEMBL4068614 | 0.79 | JAK3 (0.68) | JAK3JAK2JAK1TYK2PKN2 | |
| SCHEMBL10079943 | 0.77 | JAK3 (0.55) | JAK3JAK2JAK1TYK2PKN2 | |
| SCHEMBL353054 | 0.77 | JAK3 (0.55) | JAK3JAK2JAK1TYK2PKN2 | |
| SCHEMBL350927 | 0.74 | JAK2 (0.60) | JAK3JAK2JAK1TYK2PKN2 | |
| SCHEMBL10080592 | 0.74 | JAK2 (0.60) | JAK3JAK2JAK1TYK2PKN2 | |
| SCHEMBL352844 | 0.73 | JAK3 (0.56) | JAK3JAK2JAK1TYK2PKN2 | |
| SCHEMBL10080258 | 0.73 | JAK3 (0.56) | JAK3JAK2JAK1TYK2PKN2 | |
| SCHEMBL10080553 | 0.73 | JAK3 (0.56) | JAK3JAK2JAK1TYK2PKN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349260-A1 | JANUS KINASE INHIBITORS FOR TREATMENT OF DRY EYE AND OTHER EYE RELATED DISEASES | Incyte Corporation (US) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010039939-A1 | JANUS KINASE INHIBITORS FOR TREATMENT OF DRY EYE AND OTHER EYE RELATED DISEASES | INCYTE CORPORATION (US) | 2010-04-08 | — | — | WO | disclosed |