Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 13/20 | 0.74 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.53 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.53 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1374371 | 0.91 | S1PR1 (0.68) | S1PR1TAOK1TAOK3MTNR1AMTNR1B | |
| SCHEMBL13392751 | 0.91 | S1PR1 (0.73) | S1PR1TAOK1TAOK3LTA4HSMN1; SMN2 | |
| SCHEMBL12044808 | 0.91 | S1PR1 (0.73) | S1PR1TAOK1TAOK3SMN1; SMN2RAB9A | |
| SCHEMBL1373265 | 0.90 | S1PR1 (0.67) | S1PR1TAOK1TAOK3LTA4HSMN1; SMN2 | |
| SCHEMBL1373528 | 0.89 | S1PR1 (0.68) | S1PR1TAOK1TAOK3MTNR1AMTNR1B | |
| SCHEMBL1376155 | 0.89 | S1PR1 (0.73) | S1PR1TAOK1TAOK3LTA4HSMN1; SMN2 | |
| SCHEMBL1375817 | 0.89 | S1PR1 (0.64) | S1PR1TAOK1TAOK3MTNR1AMTNR1B | |
| SCHEMBL1374420 | 0.89 | S1PR1 (0.65) | S1PR1TAOK1TAOK3LTA4HSMN1; SMN2 | |
| SCHEMBL12044881 | 0.89 | S1PR1 (0.64) | S1PR1TAOK1TAOK3LTA4HSMN1; SMN2 | |
| SCHEMBL12044883 | 0.88 | S1PR1 (0.67) | S1PR1TAOK1TAOK3LTA4HSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349252-A2 | SYNERGISTIC COMBINATION OF SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS AND ANTIMICROTUBULE AGENTS | Exelixis, Inc. (US) | 2011-08-03 | — | — | EP | disclosed |