Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 11/20 | 0.36 |
| ▸ | MERTK | Q12866 | 5/20 | 0.35 |
| ▸ | AXL | P30530 | 4/20 | 0.35 |
| ▸ | MET | P08581 | 2/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10100705 | 0.85 | LRRK2 (0.41) | MAP4K4MAPK1MERTKAXLMET | |
| SCHEMBL2357270 | 0.85 | IRAK1 (0.40) | MAPK1MERTKAXLMET | |
| SCHEMBL2357266 | 0.84 | MAP4K4 (0.36) | MAP4K4MAPK1MERTKAXLMET | |
| SCHEMBL2365320 | 0.83 | MAPK1 (0.40) | MAP4K4MAPK1MERTKAXLMET | |
| SCHEMBL10100638 | 0.83 | LRRK2 (0.38) | MAP4K4MAPK1METLRRK2 | |
| SCHEMBL2356833 | 0.83 | LRRK2 (0.39) | MAP4K4MAPK1MERTKMETLRRK2 | |
| SCHEMBL10100381 | 0.82 | MAP4K3 (0.42) | MAP4K4METLRRK2 | |
| SCHEMBL2358758 | 0.82 | LRRK2 (0.39) | MAP4K4MAPK1METLRRK2 | |
| Hydrochloric Acid SCHEMBL2357336 | 0.81 | LRRK2 (0.39) | MAP4K4MAPK1METLRRK2 | |
| SCHEMBL10100639 | 0.81 | LRRK2 (0.40) | MAP4K4MAPK1METLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2350045-A1 | C-MET PROTEIN KINASE INHIBITORS | Vertex Pharmaceuticals Incorporated (US) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010048131-A1 | C-MET PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-04-29 | — | — | WO | disclosed |