Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.57 |
| ▸ | FGFR4 | P22455 | 9/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.49 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.49 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.49 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21166367 | 0.90 | FGFR4 (0.62) | EGFRFGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL16071678 | 0.85 | FGFR4 (0.70) | EGFRFGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL23653276 | 0.78 | EGFR (0.44) | EGFRFGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL16071424 | 0.78 | FGFR4 (0.72) | EGFRFGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL24224962 | 0.76 | FGFR4 (0.56) | FGFR4FGFR1FGFR2FGFR3MAPK3 | |
| SCHEMBL16071706 | 0.76 | FGFR4 (0.83) | EGFRFGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL16134052 | 0.75 | FGFR4 (0.76) | EGFRFGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL16071407 | 0.74 | FGFR4 (0.73) | EGFRFGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL19363575 | 0.74 | FGFR4 (0.72) | FGFR4FGFR1FGFR2 | |
| SCHEMBL16137318 | 0.73 | FGFR4 (0.79) | EGFRFGFR4FGFR1FGFR2FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968337-B1 | HETEROARYL COMPOUNDS AND USES THEREOF | CELGENE CAR LLC (BM) | 2021-07-21 | — | — | EP | disclosed |