Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | CETP | P11597 | 3/20 | 0.47 |
| ▸ | ELANE | P08246 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9939398 | 0.91 | IDO1 (0.50) | TSHRCETPELANEIDO1 | |
| SCHEMBL16394878 | 0.91 | TSHR (0.52) | TSHRCETPELANEIDO1 | |
| SCHEMBL206609 | 0.89 | TSHR (0.68) | TSHRCETPELANESRCIDO1 | |
| SCHEMBL26985923 | 0.89 | TSHR (0.55) | TSHRCETPELANESRC | |
| SCHEMBL7917113 | 0.89 | CYP3A4 (0.59) | TSHRCETPCYP3A4 | |
| SCHEMBL4948490 | 0.89 | CYP3A4 (0.59) | TSHRCETPCYP3A4 | |
| SCHEMBL5424748 | 0.89 | TSHR (0.50) | TSHRCETPELANESRC | |
| SCHEMBL9939654 | 0.89 | TSHR (0.50) | TSHRCETPELANE | |
| SCHEMBL23066881 | 0.88 | TSHR (0.49) | TSHRCETPELANESRC | |
| SCHEMBL8790528 | 0.88 | TSHR (0.53) | TSHRCETPELANESRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2348859-B1 | PRODRUGS OF OXAZOLIDINONE CETP INHIBITORS | MERCK SHARP & DOHME (US) | 2013-12-04 | — | — | EP | disclosed |
| US-8354454-B2 | Prodrugs of oxazolidinone CETP inhibitors | MERCK SHARP & DOHME CORP. (US) | 2013-01-15 | — | — | US | disclosed |
| EP-2348859-A1 | PRODRUGS OF OXAZOLIDINONE CETP INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2011-08-03 | — | — | EP | disclosed |