Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 20/20 | 0.50 |
| ▸ | RPTOR | Q8N122 | 16/20 | 0.50 |
| ▸ | MLST8 | Q9BVC4 | 16/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.42 |
| ▸ | CSF1R | P07333 | 2/20 | 0.42 |
| ▸ | PRKDC | P78527 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | FLT4 | P35916 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.31 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL138444 | 0.78 | MTOR (0.56) | MTORRPTORMLST8PIK3CACSF1R | |
| SCHEMBL22675179 | 0.68 | MTOR (0.69) | MTORRPTORMLST8PIK3CACSF1R | |
| SCHEMBL29522317 | 0.66 | MTOR (0.72) | MTORRPTORMLST8PIK3CACSF1R | |
| SCHEMBL138084 | 0.66 | MTOR (0.72) | MTORRPTORMLST8PIK3CACSF1R | |
| SCHEMBL22203977 | 0.64 | MTOR (0.65) | MTORRPTORMLST8PIK3CACSF1R | |
| SCHEMBL137335 | 0.61 | MTOR (0.53) | MTORRPTORMLST8PIK3CACSF1R | |
| SCHEMBL22675182 | 0.60 | MTOR (0.63) | MTORRPTORMLST8PIK3CACSF1R | |
| SCHEMBL153310 | 0.60 | MTOR (0.57) | MTORRPTORMLST8PIK3CACSF1R | |
| Cc-115 SCHEMBL14877034 | 0.60 | MTOR (0.69) | MTORRPTORMLST8PIK3CACSF1R | |
| Cc-115 SCHEMBL29354401 | 0.60 | MTOR (0.69) | MTORRPTORMLST8PIK3CACSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2358718-A1 | MTOR KINASE INHIBITORS FOR ONCOLOGY INDICATIONS AND DISEASES ASSOCIATED WITH THE MTOR/P13K/AKT PATHWAY | Signal Pharmaceuticals, LLC (US) | 2011-08-24 | — | — | EP | disclosed |
| WO-2010062571-A1 | MTOR KINASE INHIBITORS FOR ONCOLOGY INDICATIONS AND DISEASES ASSOCIATED WITH THE MTOR/P13K/AKT PATHWAY | SIGNAL PHARMACEUTICALS, LLC (US) | 2010-06-03 | — | — | WO | disclosed |