SCHEMBL23655486

SCHEMBL23655486

COCc1c(-c2ccc(Cl)cc2)nsc1C(F)(F)F

nearest known ligand 0.55

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FFAR4 Q5NUL3 20/20 0.55
FFAR1 O14842 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23655730 0.84 FFAR4 (0.53) FFAR4FFAR1
SCHEMBL16048633 0.83 FFAR4 (0.53) FFAR4FFAR1
SCHEMBL16047694 0.81 FFAR4 (0.53) FFAR4FFAR1
SCHEMBL28358681 0.81 FFAR4 (0.50) FFAR4FFAR1
SCHEMBL23655274 0.80 FFAR4 (0.51) FFAR4FFAR1
SCHEMBL28358479 0.78 FFAR4 (0.57) FFAR4FFAR1
SCHEMBL23655545 0.78 FFAR4 (0.47) FFAR4FFAR1
SCHEMBL16048427 0.77 FFAR4 (0.70) FFAR4FFAR1
SCHEMBL28358491 0.75 FFAR4 (0.78) FFAR4
SCHEMBL16863877 0.75 FFAR4 (0.58) FFAR4FFAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3409671-B1 ISOTHIAZOLE DERIVATIVES AS GPR120 AGONISTS FOR THE TREATMENT OF TYPE II DIABETES JANSSEN PHARMACEUTICA NV (BE) 2021-07-21 EP disclosed