Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 20/20 | 0.81 |
| ▸ | JAK2 | O60674 | 10/20 | 0.81 |
| ▸ | JAK1 | P23458 | 10/20 | 0.81 |
| ▸ | TYK2 | P29597 | 4/20 | 0.81 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.80 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.80 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.75 |
| ▸ | MARK3 | P27448 | 2/20 | 0.75 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.75 |
| ▸ | STK3 | Q13188 | 2/20 | 0.75 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.75 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.75 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.75 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.75 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.75 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.75 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.75 |
| ▸ | ABL1 | P00519 | 1/20 | 0.75 |
| ▸ | LCK | P06239 | 1/20 | 0.75 |
| ▸ | FYN | P06241 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4062775 | 1.00 | JAK3 (0.81) | JAK3JAK2JAK1TYK2PKN2 | |
| Dimethylformamide SCHEMBL27573084 | 0.95 | JAK3 (0.75) | JAK3JAK2JAK1TYK2PKN2 | |
| Biphenyl SCHEMBL28763309 | 0.95 | JAK3 (0.75) | JAK3JAK2JAK1TYK2PKN2 | |
| Diethylamine SCHEMBL27487687 | 0.94 | JAK3 (0.75) | JAK3JAK2JAK1TYK2PKN2 | |
| Benzamide SCHEMBL28763318 | 0.93 | JAK3 (0.71) | JAK3JAK2JAK1TYK2PKN2 | |
| SCHEMBL3061932 | 0.92 | JAK3 (0.81) | JAK3JAK2JAK1TYK2PKN2 | |
| SCHEMBL4866110 | 0.92 | JAK3 (0.81) | JAK3JAK2JAK1TYK2PKN2 | |
| SCHEMBL3068621 | 0.92 | JAK3 (0.81) | JAK3JAK2JAK1TYK2PKN2 | |
| SCHEMBL2319414 | 0.92 | JAK3 (0.81) | JAK3JAK2JAK1TYK2PKN2 | |
| SCHEMBL28413805 | 0.91 | JAK3 (0.89) | JAK3JAK2JAK1TYK2PKN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2363149-A1 | Combinations comprising a S1P receptor agonist and a JAK3 kinase inhibitor | Novartis AG (CH) | 2011-09-07 | — | — | EP | disclosed |