Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL388267 | 0.85 | MAP2K1 (0.48) | MAP2K1MAP2K2 | |
| SCHEMBL388554 | 0.77 | MAP2K1 (0.51) | MAP2K1MAP2K2 | |
| SCHEMBL388540 | 0.77 | MAP2K1 (0.46) | MAP2K1MAP2K2 | |
| SCHEMBL388159 | 0.76 | MAP2K1 (0.50) | MAP2K1MAP2K2 | |
| SCHEMBL391269 | 0.76 | MAP2K1 (0.48) | MAP2K1MAP2K2 | |
| SCHEMBL390240 | 0.75 | MAP2K1 (0.52) | MAP2K1MAP2K2 | |
| SCHEMBL13560150 | 0.73 | MAP2K1 (0.46) | MAP2K1MAP2K2 | |
| SCHEMBL388850 | 0.73 | MAP2K1 (0.51) | MAP2K1MAP2K2 | |
| SCHEMBL28821891 | 0.71 | MAP2K1 (0.51) | MAP2K1MAP2K2 | |
| SCHEMBL12021573 | 0.71 | MAP2K1 (0.47) | MAP2K1MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364973-B1 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC (US) | 2014-07-09 | — | — | EP | disclosed |
| EP-2364973-A1 | Heterocyclic inhibitors of MEK and Methods of use thereof | Array Biopharma, Inc. (US) | 2011-09-14 | — | — | EP | disclosed |