Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 20/20 | 0.52 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.52 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.52 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL387632 | 0.84 | MAP2K1 (0.61) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL387633 | 0.84 | MAP2K1 (0.61) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL393632 | 0.82 | MAP2K1 (0.54) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL393633 | 0.82 | MAP2K1 (0.54) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL393158 | 0.79 | MAP2K1 (0.79) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL391878 | 0.76 | MAP2K1 (0.64) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL391096 | 0.74 | MAP2K1 (0.77) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL391097 | 0.74 | MAP2K1 (0.77) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL391343 | 0.74 | MAP2K1 (0.49) | MAP2K1MAP2K2MAP2K5EIF2AK1 | |
| SCHEMBL391344 | 0.74 | MAP2K1 (0.49) | MAP2K1MAP2K2MAP2K5EIF2AK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364973-B1 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC (US) | 2014-07-09 | — | — | EP | disclosed |
| EP-2364973-A1 | Heterocyclic inhibitors of MEK and Methods of use thereof | Array Biopharma, Inc. (US) | 2011-09-14 | — | — | EP | disclosed |