SCHEMBL23658220

SCHEMBL23658220

Cc1cc(F)cc(-c2cnc(N)c(-c3nc4cc(F)cc(F)c4[nH]3)c2N2CCC(NC(=O)OC(C)(C)C)CC2)c1

nearest known ligand 0.46

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ SSTR2 P30874 16/20 0.46
▸ KCNH2 Q12809 2/20 0.40
▸ PARP1 P09874 1/20 0.40
▸ CKS1B P61024 1/20 0.38
▸ SKP1 P63208 1/20 0.38
▸ SKP2 Q13309 1/20 0.38
▸ SSTR5 P35346 1/20 0.37
▸ SYK P43405 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20500594 0.91 SSTR2 (0.44) SSTR2KCNH2PARP1CKS1BSKP1
SCHEMBL20500581 0.90 SSTR2 (0.45) SSTR2KCNH2PARP1CKS1BSKP1
SCHEMBL20500489 0.89 SSTR2 (0.44) SSTR2KCNH2PARP1CKS1BSKP1
SCHEMBL20500538 0.87 SSTR2 (0.42) SSTR2KCNH2PARP1CKS1BSKP1
SCHEMBL23658217 0.86 SSTR2 (0.51) SSTR2KCNH2PARP1CKS1BSKP1
SCHEMBL30255208 0.83 SSTR2 (0.56) SSTR2KCNH2SSTR5
SCHEMBL20500438 0.83 SSTR2 (0.56) SSTR2KCNH2SSTR5
SCHEMBL31506643 0.82 SSTR2 (0.60) SSTR2PARP1SSTR5
SCHEMBL21810266 0.82 SSTR2 (0.60) SSTR2PARP1SSTR5
SCHEMBL30897193 0.82 SSTR2 (0.49) SSTR2KCNH2PARP1CKS1BSKP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11072598-B2 Somatostatin modulators and uses thereof Crinetics Pharmaceuticals, Inc. (US) 2021-07-27 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11072598-B2 Somatostatin modulators and uses thereof SSTR5, SSTR2, SSTR4 SSTR2 2/4885KCNH2 4091/4885PARP1 4610/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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