Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24846824 | 0.86 | USP2 (0.32) | TSHRUSP2CYP2C9CYP2C19CYP2D6 | |
| SCHEMBL9963300 | 0.84 | TSHR (0.46) | TSHRUSP2CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL25888899 | 0.82 | TSHR (0.41) | TSHRUSP2CYP2C9CYP1A2CYP2D6 | |
| SCHEMBL20328927 | 0.81 | TSHR (0.43) | TSHRUSP2CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL25667600 | 0.78 | USP2 (0.36) | TSHRUSP2CYP2C9CYP2D6ALDH1A1 | |
| SCHEMBL20620447 | 0.78 | TSHR (0.49) | TSHRUSP2CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL10260816 | 0.77 | TSHR (0.51) | TSHRUSP2CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL2693754 | 0.76 | TSHR (0.50) | TSHRUSP2CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL21364233 | 0.75 | TSHR (0.46) | TSHRUSP2CYP2C9CYP2C19CYP1A2 | |
| Hydrochloric Acid SCHEMBL2126410 | 0.74 | TSHR (0.53) | TSHRUSP2CYP2C9CYP2C19CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023125908-A1 | DEGRADATION OF BRUTON'S TYROSINE KINASE (BTK) BY CONJUGATION OF BTK INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | BEIGENE, LTD. (KY) | 2023-07-06 | — | — | WO | disclosed |
| WO-2021143680-A1 | HETEROARYL DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF | 浙江海正药业股份有限公司 | 2021-07-22 | — | — | WO | disclosed |