Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 17/20 | 0.59 |
| ▸ | IKZF2 | Q9UKS7 | 3/20 | 0.55 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.50 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | TNF | P01375 | 1/20 | 0.49 |
| ▸ | IL1B | P01584 | 1/20 | 0.49 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.49 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.49 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quinoline SCHEMBL27606599 | 0.84 | CRBN (0.74) | CRBNIKZF2CSNK1A1BRD4TNF | |
| SCHEMBL23860862 | 0.80 | CRBN (0.55) | CRBNIKZF2CSNK1A1IKZF1 | |
| SCHEMBL23860878 | 0.78 | CRBN (0.55) | CRBNIKZF2CSNK1A1IKZF1 | |
| SCHEMBL30133326 | 0.78 | CRBN (0.55) | CRBNIKZF2CSNK1A1IKZF1 | |
| SCHEMBL23860972 | 0.78 | CRBN (0.55) | CRBNIKZF2CSNK1A1IKZF1 | |
| SCHEMBL30133317 | 0.78 | CRBN (0.55) | CRBNIKZF2CSNK1A1IKZF1 | |
| SCHEMBL30133346 | 0.78 | CRBN (0.57) | CRBNIKZF2CSNK1A1BRD4TNF | |
| SCHEMBL20128661 | 0.78 | CRBN (0.64) | CRBNIKZF2BRD4TNFIL1B | |
| SCHEMBL23561126 | 0.78 | CRBN (0.64) | CRBNIKZF2BRD4TNFIL1B | |
| SCHEMBL1403658 | 0.77 | CRBN (0.55) | CRBNIKZF2CSNK1A1DDB1IKZF3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021143822-A1 | BICYCLIC IMIDE DERIVATIVE, PREPARATION METHOD THEREOF, AND APPLICATION THEREOF IN MEDICINE | 江苏恒瑞医药股份有限公司 | 2021-07-22 | — | — | WO | disclosed |