Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 20/20 | 0.82 |
| ▸ | AKT2 | P31751 | 20/20 | 0.82 |
| ▸ | AKT3 | Q9Y243 | 20/20 | 0.82 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.75 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL191967 | 1.00 | AKT1 (0.82) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL191966 | 1.00 | AKT1 (0.82) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL190769 | 1.00 | AKT1 (0.82) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL190768 | 1.00 | AKT1 (0.82) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL191968 | 1.00 | AKT1 (0.82) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL190767 | 1.00 | AKT1 (0.82) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL21350085 | 0.93 | AKT1 (0.84) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL192433 | 0.92 | AKT1 (0.81) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL192435 | 0.92 | AKT1 (0.81) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL192434 | 0.92 | AKT1 (0.81) | AKT1AKT2AKT3PIK3CAPRKG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049501-B1 | HYDROXYLATED AND METHOXYLATED CYCLOPENTA [D] PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2011-09-14 | — | — | EP | disclosed |