Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 15/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | TNKS | O95271 | 2/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.39 |
| ▸ | XDH | P47989 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30291425 | 1.00 | TYMS (0.41) | TYMSKDM1ATNKSTNKS2XDH | |
| SCHEMBL25551766 | 0.83 | HPGD (0.41) | TNKSTNKS2 | |
| SCHEMBL30067270 | 0.83 | HPGD (0.41) | TNKSTNKS2 | |
| SCHEMBL23668852 | 0.80 | TYMS (0.43) | TYMSTNKSTNKS2 | |
| SCHEMBL24483582 | 0.79 | HPGD (0.43) | TNKSTNKS2 | |
| SCHEMBL23630258 | 0.75 | KDM1A (0.40) | KDM1ATNKSTNKS2 | |
| SCHEMBL23668853 | 0.75 | TYMS (0.41) | TYMSTNKSTNKS2 | |
| SCHEMBL23645122 | 0.75 | KDM1A (0.41) | KDM1A | |
| SCHEMBL23645263 | 0.72 | KDM1A (0.44) | KDM1A | |
| SCHEMBL25419112 | 0.70 | KDM1A (0.37) | KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11312724-B2 | Spirocyclic tetrahydroquinazolines | ASCENTAGE PHARMA (SUZHOU) CO., LTD. | 2022-04-26 | — | — | US | disclosed |
| US-20210230174-A1 | SPIROCYCLIC TETRAHYDROQUINAZOLINES | ASCENTAGE PHARMA (SUZHOU) CO., LTD. (CN) | 2021-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210230174-A1 | SPIROCYCLIC TETRAHYDROQUINAZOLINES | KRAS, NRAS, HRAS | TYMS 1097/4885KDM1A 3827/4885TNKS 1508/4885 |
| US-11312724-B2 | Spirocyclic tetrahydroquinazolines | KRAS, NRAS, HRAS | TYMS 1097/4885KDM1A 3827/4885TNKS 1508/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.