Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.59 |
| ▸ | HTR1A | P08908 | 2/20 | 0.59 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.59 |
| ▸ | HTR1D | P28221 | 1/20 | 0.59 |
| ▸ | HTR1B | P28222 | 1/20 | 0.59 |
| ▸ | HTR2C | P28335 | 1/20 | 0.59 |
| ▸ | HTR1E | P28566 | 1/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.59 |
| ▸ | HTR7 | P34969 | 1/20 | 0.59 |
| ▸ | HTR2B | P41595 | 1/20 | 0.59 |
| ▸ | HTR6 | P50406 | 1/20 | 0.59 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | APAF1 | O14727 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23679536 | 0.87 | HTR2A (0.57) | HTR2AHTR1AADRB1ADRA2ASLC6A2 | |
| SCHEMBL16174125 | 0.85 | HTR2A (0.63) | HTR2AHTR1AADRB1ADRA2ASLC6A2 | |
| SCHEMBL16203421 | 0.84 | HTR2A (0.56) | HTR2AHTR1AADRB1ADRA2ASLC6A2 | |
| SCHEMBL13594308 | 0.84 | HTR2A (0.56) | HTR2AHTR1AADRB1ADRA2ASLC6A2 | |
| SCHEMBL23679540 | 0.82 | HTR2A (0.56) | HTR2AHTR1AADRB1ADRA2ASLC6A2 | |
| SCHEMBL3247538 | 0.81 | HTR2A (0.66) | HTR2AHTR1AADRB1ADRA2ASLC6A2 | |
| SCHEMBL13115481 | 0.81 | HTR2A (0.54) | HTR2AHTR1AADRB1ADRA2ASLC6A2 | |
| SCHEMBL827572 | 0.81 | HTR2A (0.74) | HTR2AHTR1AADRB1ADRA2ASLC6A2 | |
| SCHEMBL18822721 | 0.80 | HTR2A (0.74) | HTR2AHTR1AADRB1ADRA2ASLC6A2 | |
| SCHEMBL23679805 | 0.80 | HTR2A (0.54) | HTR2AHTR1AADRB1ADRA2ASLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3328379-B1 | BIS-HETEROARYL DERIVATIVES AS MODULATORS OF PROTEIN AGGREGATION | UCB Biopharma SRL (BE) | 2021-07-28 | — | — | EP | disclosed |