Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | SNCA | P37840 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TTK | P33981 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23046941 | 0.78 | KDM4E (0.40) | YTHDC1KDM4ESTAT3HIF1ATSHR | |
| SCHEMBL23352307 | 0.77 | KDM4E (0.39) | YTHDC1KDM4ESTAT3HIF1ATSHR | |
| SCHEMBL1326632 | 0.75 | KDM4E (0.46) | YTHDC1KDM4ESTAT3HIF1ATSHR | |
| SCHEMBL23679805 | 0.74 | HTR2A (0.54) | KDM4ESNCACYP3A4ALDH1A1 | |
| SCHEMBL18455839 | 0.74 | HTR2A (0.54) | KDM4ESNCACYP3A4ALDH1A1 | |
| SCHEMBL2876088 | 0.73 | MEN1 (0.45) | KDM4EGAAPDPK1CYP3A4CYP1A2 | |
| SCHEMBL9963337 | 0.73 | KDM4E (0.47) | YTHDC1KDM4ESTAT3HIF1AGAA | |
| SCHEMBL29117330 | 0.72 | MEN1 (0.47) | KDM4EGAAPDPK1CYP3A4CYP1A2 | |
| SCHEMBL3347649 | 0.71 | KDM4E (0.48) | YTHDC1KDM4ESTAT3HIF1ATSHR | |
| SCHEMBL254885 | 0.70 | KDM4E (0.52) | YTHDC1KDM4ESTAT3HIF1AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3328379-B1 | BIS-HETEROARYL DERIVATIVES AS MODULATORS OF PROTEIN AGGREGATION | UCB Biopharma SRL (BE) | 2021-07-28 | — | — | EP | disclosed |