Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 8/20 | 0.55 |
| ▸ | MGLL | Q99685 | 1/20 | 0.47 |
| ▸ | VNN1 | O95497 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.36 |
| ▸ | DDR1 | Q08345 | 3/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | ACACA | Q13085 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24463716 | 0.90 | HPGD (0.56) | HPGDMGLLVNN1LRRK2ADRA1A | |
| SCHEMBL23675335 | 0.88 | HPGD (0.51) | HPGDMGLLVNN1LRRK2ADRA1A | |
| SCHEMBL23675201 | 0.88 | HPGD (0.54) | HPGDMGLLVNN1LRRK2ADRA1A | |
| SCHEMBL23680616 | 0.88 | HPGD (0.61) | HPGDMGLLVNN1LRRK2ADRA1A | |
| SCHEMBL24329043 | 0.88 | HPGD (0.54) | HPGDMGLLVNN1LRRK2ADRA1A | |
| SCHEMBL29565750 | 0.87 | HPGD (0.54) | HPGDMGLLVNN1LRRK2ADRA1A | |
| SCHEMBL23680713 | 0.87 | HPGD (0.53) | HPGDMGLLVNN1LRRK2ADRA1A | |
| SCHEMBL23675180 | 0.86 | HPGD (0.58) | HPGDMGLLVNN1LRRK2ADRA1A | |
| SCHEMBL24463672 | 0.86 | HPGD (0.52) | HPGDMGLLVNN1LRRK2ADRA1A | |
| SCHEMBL24942618 | 0.86 | HPGD (0.55) | HPGDMGLLVNN1LRRK2ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021151014-A1 | PGDH INHIBITORS AND METHODS OF MAKING AND USING | MYOFORTE THERAPEUTICS, INC. (US) | 2021-07-29 | — | — | WO | disclosed |