Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 18/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | HMOX2 | P30519 | 1/20 | 0.44 |
| ▸ | CRYZ | Q08257 | 1/20 | 0.44 |
| ▸ | VAT1 | Q99536 | 1/20 | 0.44 |
| ▸ | RTN4 | Q9NQC3 | 1/20 | 0.44 |
| ▸ | OTUD7B | Q6GQQ9 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30117913 | 0.86 | KRAS (0.56) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL23668563 | 0.86 | KRAS (0.56) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL23668571 | 0.84 | KRAS (0.59) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL30485557 | 0.84 | KRAS (0.59) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL23668553 | 0.83 | KRAS (0.57) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL30485556 | 0.76 | KRAS (0.47) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL23668580 | 0.76 | KRAS (0.47) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL21099341 | 0.76 | KRAS (0.58) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL18963685 | 0.71 | KRAS (0.61) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL23668577 | 0.70 | KRAS (0.41) | KRASEGFRHMOX2CRYZVAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11530218-B2 | Spiro compounds as inhibitors of KRAS | INCYTE CORPORATION (US) | 2022-12-20 | — | — | US | disclosed |
| US-20210230162-A1 | SPIRO COMPOUNDS AS INHIBITORS OF KRAS | INCYTE CORPORATION | 2021-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210230162-A1 | SPIRO COMPOUNDS AS INHIBITORS OF KRAS | KRAS, HRAS, NRAS | KRAS 1/4885EGFR 935/4885HMOX2 2716/4885 |
| US-11530218-B2 | Spiro compounds as inhibitors of KRAS | KRAS, HRAS, NRAS | KRAS 1/4885EGFR 672/4885HMOX2 3154/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.