Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 18/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 9/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4710661 | 0.85 | HDAC1 (0.48) | HDAC1HDAC3HDAC6HDAC4HDAC7 | |
| Trifluoroacetic Acid SCHEMBL2369022 | 0.85 | HDAC1 (0.48) | HDAC1HDAC3HDAC6HDAC4HDAC7 | |
| SCHEMBL2368392 | 0.78 | HDAC1 (0.56) | HDAC1HDAC3HDAC6HDAC4HDAC7 | |
| SCHEMBL15512801 | 0.74 | HDAC1 (0.57) | HDAC1HDAC3HDAC6HDAC4HDAC7 | |
| SCHEMBL2071137 | 0.74 | HDAC1 (0.36) | HDAC1HDAC3HDAC6HDAC4HDAC7 | |
| SCHEMBL5277764 | 0.74 | HDAC1 (0.36) | HDAC1HDAC3HDAC6HDAC4HDAC7 | |
| SCHEMBL5274853 | 0.74 | HDAC1 (0.66) | HDAC1HDAC3HDAC6HDAC4HDAC7 | |
| SCHEMBL2071983 | 0.74 | HDAC1 (0.66) | HDAC1HDAC3HDAC6HDAC4HDAC7 | |
| Trifluoroacetic Acid SCHEMBL2368389 | 0.74 | HDAC1 (0.59) | HDAC1HDAC3HDAC6HDAC4HDAC7 | |
| Trifluoroacetic Acid SCHEMBL2368587 | 0.73 | HDAC1 (0.57) | HDAC1HDAC3HDAC6HDAC4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8026265-B2 | Heterocycle substituted ketone derivatives as histone deacetylase (HDAC) inhibitors | Istituto de Ricerche di Biologia Molecolare P. Angeletti SpA. (IT) | 2011-09-27 | — | — | US | disclosed |
| US-20100234374-A1 | Heterocycle Substituted Ketone Derivatives as Histone Deacetylase (HDAC) Inhibitors | MSD ITALIA S.R.L. (IT) | 2010-09-16 | — | — | US | disclosed |
| EP-1976834-A2 | HETEROCYCLE SUBSTITUTED KETONE DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2008-10-08 | — | — | EP | disclosed |
| WO-2007072080-A2 | HETEROCYCLE SUBSTITUTED KETONE DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2007-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100234374-A1 | Heterocycle Substituted Ketone Derivatives as Histone Deacetylase (HDAC) Inhibitors | HDAC1, HDAC7, HDAC4 | HDAC1 1/4885HDAC3 8/4885HDAC6 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.