Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.73 |
| ▸ | TNF | P01375 | 2/20 | 0.73 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.73 |
| ▸ | POLB | P06746 | 1/20 | 0.73 |
| ▸ | PKM | P14618 | 1/20 | 0.73 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.73 |
| ▸ | CCNC | P24863 | 1/20 | 0.59 |
| ▸ | CDK8 | P49336 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 5/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | STAT3 | P40763 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2369091 | 0.88 | SMN1; SMN2 (0.64) | SMN1; SMN2ALDH1A1TNFNOD1POLB | |
| SCHEMBL3387875 | 0.86 | SMN1; SMN2 (0.71) | SMN1; SMN2ALDH1A1TNFNOD1POLB | |
| SCHEMBL3383720 | 0.85 | SMN1; SMN2 (0.60) | SMN1; SMN2ALDH1A1TNFNOD1POLB | |
| SCHEMBL2369277 | 0.85 | CCNC (0.78) | SMN1; SMN2ALDH1A1TNFNOD1CCNC | |
| SCHEMBL2368782 | 0.82 | SMN1; SMN2 (0.59) | SMN1; SMN2ALDH1A1TNFNOD1POLB | |
| SCHEMBL2368835 | 0.81 | SMN1; SMN2 (0.65) | SMN1; SMN2ALDH1A1TNFNOD1POLB | |
| SCHEMBL3382531 | 0.81 | SMN1; SMN2 (0.65) | SMN1; SMN2ALDH1A1TNFNOD1POLB | |
| SCHEMBL2369385 | 0.81 | SMN1; SMN2 (0.64) | SMN1; SMN2ALDH1A1TNFNOD1POLB | |
| SCHEMBL3385124 | 0.80 | SMN1; SMN2 (0.62) | SMN1; SMN2ALDH1A1TNFNOD1POLB | |
| SCHEMBL2368781 | 0.79 | MAPK1 (0.65) | SMN1; SMN2ALDH1A1TNFNOD1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8022076-B2 | Thieno[2,3-d]pyrimidine derivatives as potassium channel modulators; antiarrhythmia agents | XENTION LIMITED (GB) | 2011-09-20 | — | — | US | disclosed |
| EP-1641803-B3 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION LTD (GB) | 2010-12-08 | — | — | EP | disclosed |
| EP-1641803-B1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION LTD (GB) | 2009-03-18 | — | — | EP | disclosed |
| EP-1641803-A1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | Xention Discovery Limited (GB) | 2006-04-05 | — | — | EP | disclosed |
| WO-2004111057-A1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION DISCOVERY LIMITED (GB) | 2004-12-23 | — | — | WO | disclosed |