Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 15/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 10/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2368392 | 0.78 | HDAC1 (0.56) | HDAC1HDAC3HDAC6HDAC8HDAC2 | |
| SCHEMBL2073400 | 0.74 | HDAC1 (0.49) | HDAC1HDAC3HDAC6HDAC8HDAC2 | |
| SCHEMBL5273613 | 0.74 | HDAC1 (0.49) | HDAC1HDAC3HDAC6HDAC8HDAC2 | |
| Hydrochloric Acid SCHEMBL2072808 | 0.72 | HDAC1 (0.45) | HDAC1HDAC3HDAC6HDAC8HDAC2 | |
| SCHEMBL5278894 | 0.72 | HDAC1 (0.45) | HDAC1HDAC3HDAC6HDAC8HDAC2 | |
| Hydrochloric Acid SCHEMBL2073570 | 0.71 | HDAC1 (0.64) | HDAC1HDAC3HDAC6HDAC8HDAC2 | |
| SCHEMBL15671423 | 0.70 | HDAC1 (0.41) | HDAC1HDAC3HDAC6HDAC8HDAC2 | |
| SCHEMBL2072442 | 0.67 | HDAC1 (0.41) | HDAC1HDAC3HDAC6HDAC8HDAC2 | |
| Trifluoroacetic Acid SCHEMBL2368389 | 0.67 | HDAC1 (0.59) | HDAC1HDAC3HDAC6HDAC8HDAC2 | |
| SCHEMBL2075093 | 0.66 | HDAC1 (0.39) | HDAC1HDAC3HDAC6HDAC8HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8026265-B2 | Heterocycle substituted ketone derivatives as histone deacetylase (HDAC) inhibitors | Istituto de Ricerche di Biologia Molecolare P. Angeletti SpA. (IT) | 2011-09-27 | — | — | US | disclosed |
| US-20100234374-A1 | Heterocycle Substituted Ketone Derivatives as Histone Deacetylase (HDAC) Inhibitors | MSD ITALIA S.R.L. (IT) | 2010-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100234374-A1 | Heterocycle Substituted Ketone Derivatives as Histone Deacetylase (HDAC) Inhibitors | HDAC1, HDAC7, HDAC4 | HDAC1 1/4885HDAC3 8/4885HDAC6 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.