Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 2/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | SCD | O00767 | 1/20 | 0.36 |
| ▸ | HSPB1 | P04792 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25346294 | 0.85 | TDP1 (0.51) | TDP1ATMFAAHACHEALDH1A1 | |
| Hydrochloric Acid SCHEMBL2369289 | 0.84 | PRKCQ (0.42) | TDP1ATMFAAHACHEALDH1A1 | |
| Hydrochloric Acid SCHEMBL2369727 | 0.84 | PRKCQ (0.42) | TDP1ATMFAAHACHEALDH1A1 | |
| Hydrochloric Acid SCHEMBL2369725 | 0.84 | PRKCQ (0.42) | TDP1ATMFAAHACHEALDH1A1 | |
| SCHEMBL2369024 | 0.81 | TDP1 (0.45) | TDP1ATMFAAHACHEALDH1A1 | |
| SCHEMBL2369029 | 0.81 | TDP1 (0.45) | TDP1ATMFAAHACHEALDH1A1 | |
| SCHEMBL2370046 | 0.81 | TDP1 (0.45) | TDP1ATMFAAHACHEALDH1A1 | |
| SCHEMBL12256680 | 0.81 | TDP1 (0.45) | TDP1ATMFAAHACHEALDH1A1 | |
| SCHEMBL2391267 | 0.81 | TDP1 (0.40) | TDP1ATMFAAHACHEALDH1A1 | |
| Hydrochloric Acid SCHEMBL2370171 | 0.80 | TDP1 (0.44) | TDP1ATMFAAHACHEALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2539345-A1 | 4 - [CYCLOALKYLOXY (HETERO) ARYLAMINO]THIENO [2, 3 - D]PYRIMIDINES HAVING MNKL/ MNK2 INHIBITING ACTIVITY FOR PHARMACEUTICAL COMPOSITIONS | Boehringer Ingelheim International GmbH (DE) | 2013-01-02 | — | — | EP | disclosed |
| WO-2011104334-A1 | 4 - [CYCLOALKYLOXY (HETERO) ARYLAMINO] THIENO [2, 3 - D] PYRIMIDINES HAVING MNKL/ MNK2 INHIBITING ACTIVITY FOR PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-09-01 | — | — | WO | disclosed |