Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 14/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.47 |
| ▸ | MTOR | P42345 | 7/20 | 0.45 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2369979 | 0.91 | PIK3CD (0.59) | PIK3CAPIK3CDMTORPIK3R1 | |
| SCHEMBL2369976 | 0.91 | PIK3CD (0.59) | PIK3CAPIK3CDMTORPIK3R1 | |
| SCHEMBL2370011 | 0.90 | PIK3CA (0.48) | PIK3CAPIK3CDMTORPIK3R1 | |
| SCHEMBL2370013 | 0.90 | PIK3CA (0.48) | PIK3CAPIK3CDMTORPIK3R1 | |
| SCHEMBL2369530 | 0.90 | PIK3CA (0.48) | PIK3CAPIK3CDMTORPIK3R1 | |
| SCHEMBL2369523 | 0.90 | PIK3CA (0.48) | PIK3CAPIK3CDMTORPIK3R1 | |
| SCHEMBL14471524 | 0.89 | PIK3CA (0.56) | PIK3CAPIK3CDMTOR | |
| SCHEMBL15144967 | 0.89 | PIK3CA (0.43) | PIK3CAPIK3CDMTORPIK3R1 | |
| SCHEMBL2369793 | 0.89 | PIK3CA (0.51) | PIK3CAPIK3CDMTOR | |
| SCHEMBL2369671 | 0.89 | PIK3CA (0.58) | PIK3CAPIK3CDMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2542536-B1 | Morpholino substituted urea derivatives as mtor inhibitors | CELLZOME LTD (GB) | 2015-01-21 | — | — | EP | disclosed |
| EP-2542536-A1 | MORPHOLINO SUBSTITUTED UREA DERIVATIVES AS MTOR INHIBITORS | Cellzome Limited (GB) | 2013-01-09 | — | — | EP | disclosed |
| WO-2011107585-A1 | MORPHOLINO SUBSTITUTED UREA DERIVATIVES AS MTOR INHIBITORS | CELLZOME LIMITED (GB) | 2011-09-09 | — | — | WO | disclosed |