Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 12/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 11/20 | 0.46 |
| ▸ | LCK | P06239 | 10/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | INSR | P06213 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | TEC | P42680 | 1/20 | 0.39 |
| ▸ | TXK | P42681 | 1/20 | 0.39 |
| ▸ | BMX | P51813 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2369835 | 1.00 | ITK (0.46) | ITKAURKBLCKPIK3CGIRAK4 | |
| SCHEMBL2425957 | 0.93 | PIK3CG (0.43) | ITKAURKBLCKPIK3CGIRAK4 | |
| SCHEMBL2425952 | 0.93 | PIK3CG (0.43) | ITKAURKBLCKPIK3CGIRAK4 | |
| SCHEMBL2415082 | 0.88 | ITK (0.45) | ITKAURKBLCKPIK3CGIRAK4 | |
| SCHEMBL2415079 | 0.88 | ITK (0.45) | ITKAURKBLCKPIK3CGIRAK4 | |
| SCHEMBL2370067 | 0.86 | ITK (0.48) | ITKAURKBLCKPIK3CGIRAK4 | |
| SCHEMBL2370070 | 0.86 | ITK (0.48) | ITKAURKBLCKPIK3CGIRAK4 | |
| SCHEMBL2396414 | 0.86 | ITK (0.49) | ITKAURKBLCKPIK3CGIRAK4 | |
| SCHEMBL2396612 | 0.86 | ITK (0.49) | ITKAURKBLCKPIK3CGIRAK4 | |
| SCHEMBL2396623 | 0.86 | ITK (0.49) | ITKAURKBLCKPIK3CGIRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011110575-A1 | DERIVATIVES OF 2-[2-(BENZO- OR PYRIDO-) THIAZOLYLAMINO]-6-AMINOPYRIDINE, USEFUL IN THE TREATMENT OF RESPIRATORIC, ALLERGIC OR INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2011-09-15 | — | — | WO | disclosed |