Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | IDH1 | O75874 | 5/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NAAA | Q02083 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | IL6ST | P40189 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21447357 | 1.00 | HPGD (0.45) | HPGDRAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL4684591 | 1.00 | HPGD (0.45) | HPGDRAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL12634643 | 1.00 | HPGD (0.45) | HPGDRAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL23699056 | 1.00 | HPGD (0.45) | HPGDRAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL4684580 | 1.00 | HPGD (0.45) | HPGDRAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL5234399 | 0.92 | NPC1 (0.41) | HPGDRAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL5234391 | 0.92 | NPC1 (0.41) | HPGDRAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL2892373 | 0.92 | IDH1 (0.46) | HPGDRAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL18262594 | 0.90 | IDH1 (0.43) | HPGDRAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL18271440 | 0.90 | IDH1 (0.43) | HPGDRAB9ANPC1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3858439-A1 | AMIDE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2021-08-04 | — | — | EP | disclosed |
| EP-3858438-A1 | 3,4-DIHYDRO-2H-SPIRO[ISOQUINOLINE-1,4'-PIPERIDIN]AMIDE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2021-08-04 | — | — | EP | disclosed |
| EP-3858810-A1 | DIALKYLAMINOARYLCYCLOALKYLAMIDE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2021-08-04 | — | — | EP | disclosed |