SCHEMBL23699585

SCHEMBL23699585

COc1cccc(C(C)NC(=O)N2CCN(c3ncnc4cc(-c5ccc(F)cc5)sc34)C[C@H]2C)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
KIT P10721 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15664149 1.00 KIT (1.00) KIT
SCHEMBL15504627 1.00 KIT (1.00) KIT
SCHEMBL15664444 0.94 KIT (1.00) KIT
SCHEMBL15504629 0.92 KIT (1.00) KIT
SCHEMBL15664068 0.90 KIT (0.85) KIT
SCHEMBL15665076 0.90 KIT (1.00) KIT
SCHEMBL23699587 0.90 KIT (1.00) KIT
SCHEMBL15663877 0.90 KIT (1.00) KIT
SCHEMBL15664514 0.85 KIT (1.00) KIT
SCHEMBL23699613 0.85 KIT (1.00) KIT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2892534-B1 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR PLEXXIKON INC (US) 2021-08-04 EP disclosed