Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC5A2 | P31639 | 18/20 | 0.51 |
| ▸ | SLC5A1 | P13866 | 10/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | SLC5A11 | Q8WWX8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16457243 | 0.83 | SLC5A2 (0.59) | SLC5A2SLC5A1ADRA2ASLC5A11 | |
| SCHEMBL16457244 | 0.83 | SLC5A2 (0.59) | SLC5A2SLC5A1ADRA2ASLC5A11 | |
| SCHEMBL1039664 | 0.83 | SLC5A2 (0.59) | SLC5A2SLC5A1ADRA2ASLC5A11 | |
| SCHEMBL2370373 | 0.78 | SLC5A2 (0.49) | SLC5A2SLC5A1ADRA2ASLC5A11 | |
| SCHEMBL25511558 | 0.74 | SLC5A2 (0.58) | SLC5A2SLC5A1ADRA2ASLC5A11 | |
| SCHEMBL11313959 | 0.73 | SLC5A2 (0.55) | SLC5A2SLC5A1ADRA2ASLC5A11 | |
| SCHEMBL28970412 | 0.73 | SLC5A2 (0.74) | SLC5A2SLC5A1ADRA2ASLC5A11 | |
| SCHEMBL28852291 | 0.73 | SLC5A2 (0.74) | SLC5A2SLC5A1ADRA2ASLC5A11 | |
| SCHEMBL28970411 | 0.73 | SLC5A2 (0.74) | SLC5A2SLC5A1ADRA2ASLC5A11 | |
| SCHEMBL1666220 | 0.73 | SLC5A2 (0.72) | SLC5A2SLC5A1ADRA2ASLC5A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2661256-A1 | COMPOSITIONS COMPRISING AND METHODS OF USING INHIBITORS OF SODIUM-GLUCOSE COTRANSPORTERS 1 AND 2 | Lexicon Pharmaceuticals, Inc. (US) | 2013-11-13 | — | — | EP | disclosed |
| EP-2542236-A1 | 6 -BENZYLPHENYL- 2 - SULFURTERAHYDROPYRAN-3, 4, 5 -TRIOL DERIVATIVES AS INHIBITORS OF SODIUM -GLUCOSE COTRANS PORTERS 1 AND 2 FOR USE IN DIABETIC PATIENTS | Lexicon Pharmaceuticals, Inc. (US) | 2013-01-09 | — | — | EP | disclosed |
| WO-2012094293-A1 | COMPOSITIONS COMPRISING AND METHODS OF USING INHIBITORS OF SODIUM-GLUCOSE COTRANSPORTERS 1 AND 2 | LEXICON PHARMACEUTICALS, INC. (US) | 2012-07-12 | — | — | WO | disclosed |
| WO-2011109333-A1 | 6 -BENZYLPHENYL- 2 - SULFURTERAHYDROPYRAN-3, 4, 5 -TRIOL DERIVATIVES AS INHIBITORS OF SODIUM -GLUCOSE COTRANS PORTERS 1 AND 2 FOR USE IN DIABETIC PATIENTS | LEXICON PHARMACEUTICALS, INC. (US) | 2011-09-09 | — | — | WO | disclosed |
| EP-2089361-A2 | INHIBITORS OF SODIUM GLUCOSE CO-TRANSPORTER 2 AND METHODS OF THEIR USE | Lexicon Pharmaceuticals, Inc. (US) | 2009-08-19 | — | — | EP | disclosed |
| WO-2008109591-A1 | PHLORIZIN ANALOGS AS INHIBITORS OF SODIUM GLUCOSE CO-TRANSPORTER 2 | LEXICON PHARMACEUTICALS, INC. (US) | 2008-09-12 | — | — | WO | disclosed |
| WO-2008042688-A2 | PHLORIZIN ANALOGS AS INHIBITORS OF SODIUM GLUCOSE CO-TRANSPORTER 2 | LEXICON PHARMACEUTICALS, INC. (US) | 2008-04-10 | — | — | WO | disclosed |