Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2434662 | 1.00 | ATM (0.69) | ATMSMN1; SMN2CYP2D6POLBHTT | |
| SCHEMBL2370052 | 1.00 | ATM (0.69) | ATMSMN1; SMN2CYP2D6POLBHTT | |
| SCHEMBL743699 | 0.90 | ATM (0.73) | ATMSMN1; SMN2CHRM3CYP1A2 | |
| SCHEMBL1365118 | 0.90 | ATM (0.73) | ATMSMN1; SMN2CHRM3CYP1A2 | |
| SCHEMBL743700 | 0.90 | ATM (0.73) | ATMSMN1; SMN2CHRM3CYP1A2 | |
| SCHEMBL9906129 | 0.83 | ATM (0.46) | ATMSMN1; SMN2CYP2D6POLBHTT | |
| SCHEMBL16014639 | 0.82 | ATM (1.00) | ATMCHRM3 | |
| SCHEMBL2928686 | 0.79 | ATM (0.67) | ATMCHRM3MEN1KMT2A | |
| SCHEMBL3694182 | 0.77 | SMN1; SMN2 (0.61) | ATMSMN1; SMN2CYP2D6POLBHTT | |
| SCHEMBL28339538 | 0.77 | SMN1; SMN2 (0.61) | ATMSMN1; SMN2CYP2D6POLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2368876-A1 | Derivatives of aminoindanes, their preparation and their application in therapeutics | SANOFI (FR) | 2011-09-28 | — | — | EP | disclosed |
| WO-2011107474-A1 | DERIVATIVES OF AMINOINDANES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS | SANOFI-AVENTIS (FR) | 2011-09-09 | — | — | WO | disclosed |
| US-8012956-B2 | Tropane compounds | EXELIXIS, INC. (US) | 2011-09-06 | — | — | US | disclosed |