Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 10/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 11/20 | 0.47 |
| ▸ | LCK | P06239 | 8/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.46 |
| ▸ | PRKCG | P05129 | 2/20 | 0.46 |
| ▸ | PRKACA | P17612 | 2/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.46 |
| ▸ | AKT1 | P31749 | 2/20 | 0.46 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.46 |
| ▸ | CLK2 | P49760 | 2/20 | 0.46 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.46 |
| ▸ | PRKX | P51817 | 2/20 | 0.46 |
| ▸ | NEK4 | P51957 | 2/20 | 0.46 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.46 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.46 |
| ▸ | HIPK4 | Q8NE63 | 2/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2370095 | 1.00 | ITK (0.51) | ITKAURKBLCKMAP4K4PRKCG | |
| SCHEMBL2396683 | 0.92 | ITK (0.57) | ITKAURKBLCKEGFRINSR | |
| SCHEMBL2396679 | 0.92 | ITK (0.57) | ITKAURKBLCKEGFRINSR | |
| SCHEMBL2369722 | 0.89 | PIK3CA (0.52) | ITKAURKBLCKEGFRINSR | |
| SCHEMBL2369714 | 0.89 | PIK3CA (0.52) | ITKAURKBLCKEGFRINSR | |
| SCHEMBL2370620 | 0.86 | ITK (0.54) | ITKAURKBLCKEGFRINSR | |
| SCHEMBL2370626 | 0.86 | ITK (0.54) | ITKAURKBLCKEGFRINSR | |
| SCHEMBL2399394 | 0.86 | PIK3CG (0.52) | ITKAURKBLCKCLK2DYRK1A | |
| SCHEMBL2399382 | 0.86 | PIK3CG (0.52) | ITKAURKBLCKCLK2DYRK1A | |
| SCHEMBL2396030 | 0.85 | ITK (0.49) | ITKAURKBLCKEGFRINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011110575-A1 | DERIVATIVES OF 2-[2-(BENZO- OR PYRIDO-) THIAZOLYLAMINO]-6-AMINOPYRIDINE, USEFUL IN THE TREATMENT OF RESPIRATORIC, ALLERGIC OR INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2011-09-15 | — | — | WO | disclosed |