SCHEMBL2370342

SCHEMBL2370342

COc1ccc(C=NN=C(N)NO)c(Cl)c1OC

nearest known ligand 0.50

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.50
GRIN2D O15399 4/20 0.43
GRIN3B O60391 4/20 0.43
GRIN1 Q05586 4/20 0.43
GRIN2A Q12879 4/20 0.43
GRIN2B Q13224 4/20 0.43
GRIN2C Q14957 4/20 0.43
GRIN3A Q8TCU5 4/20 0.43
KDM4E B2RXH2 2/20 0.43
LMNA P02545 2/20 0.43
MAPT P10636 2/20 0.43
PPP1R15A O75807 1/20 0.38
MELK Q14680 1/20 0.38
PPP1R15B Q5SWA1 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
HCAR2 Q8TDS4 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29379603 1.00 POLB (0.50) POLBGRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL4697716 0.87 MAPT (0.52) POLBGRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL4697826 0.76 MAPT (0.54) POLBKDM4ELMNAMAPTNPSR1
SCHEMBL914992 0.76 MAPT (0.54) POLBKDM4ELMNAMAPTNPSR1
SCHEMBL4946232 0.75 POLB (0.57) POLBKDM4ELMNAMAPTL3MBTL1
SCHEMBL4946236 0.75 POLB (0.57) POLBKDM4ELMNAMAPTL3MBTL1
SCHEMBL529833 0.75 MAPT (0.55) POLBKDM4ELMNAMAPTNPSR1
SCHEMBL530029 0.75 MAPT (0.55) POLBKDM4ELMNAMAPTNPSR1
SCHEMBL398854 0.74 MAPT (0.48) POLBKDM4ELMNAMAPTL3MBTL1
SCHEMBL398853 0.74 MAPT (0.48) POLBKDM4ELMNAMAPTL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 109 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008157537-A2 COMPOSITIONS AND METHODS OF USE FOR TREATING OR PREVENTING LIPID RELATED DISORDERS IRONWOOD PHARMACEUTICALS, INC (US) 2008-12-24 WO claimed
WO-2008124505-A2 SOLUBLE GUANYLATE CYCLASE (SGC) MODULATORS FOR TREATMENT OF LIPID RELATED DISORDERS IRONWOOD PHARMACEUTICALS,INC. (US) 2008-10-16 WO claimed
WO-2024086179-A1 PYRIMIDINE SGC STIMULATORS TISENTO THERAPEUTICS, INC. (US) 2024-04-25 WO disclosed
WO-2024086182-A1 TREATMENT OF MITOCHONDRIAL DISEASES WITH SGC STIMULATORS TISENTO THERAPEUTICS INC. (US) 2024-04-25 WO disclosed
EP-4326268-A1 TREATMENT OF CNS DISEASES WITH SGC STIMULATORS Tisento Therapeutics Inc. (US) 2024-02-28 EP disclosed
EP-4326722-A1 SGC STIMULATORS Tisento Therapeutics Inc. (US) 2024-02-28 EP disclosed
WO-2023018795-A1 NEP INHIBITORS FOR THE TREATMENT OF LAMINITIS CURTAILS LLC (US) 2023-02-16 WO disclosed
WO-2022265984-A1 USE OF NEP INHIBITORS FOR THE TREATMENT OF GASTROINTESTINAL SPHINCTER DISORDERS CURTAILS LLC (US) 2022-12-22 WO disclosed
WO-2022225902-A1 TREATMENT OF CNS DISEASES WITH SGC STIMULATORS CYCLERION THERAPEUTICS, INC. (US) 2022-10-27 WO disclosed
WO-2021202546-A1 EARLY DRUG INTERVENTIONS TO REDUCE COVID-19 RELATED RESPIRATORY DISTRESS, NEED FOR VENTILATOR ASSISTANCE AND DEATH CYCLERION THERAPEUTICS, INC. (US) 2021-10-07 WO disclosed
WO-2021195403-A1 DEUTERATED SGC STIMULATORS CYCLERION THERAPEUTICS, INC. (US) 2021-09-30 WO disclosed
EP-1668008-A2 NITROSATED AD NITROSYLATED DIURETIC COMPOUDS, COMPOSITIONS AND METHODS OF USE Nitromed, Inc. (US) 2006-06-14 EP disclosed
WO-2006055542-A2 DIURETIC COMPOUNDS COMPRISING HETEROCYCLIC NITRIC OXIDE DONOR GROUPS, COMPOSITIONS AND METHODS OF USE NITROMED, INC. (US) 2006-05-26 WO disclosed
WO-2006052899-A2 NITROSATED AND NITROSYLATED COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF OPHTHALMIC DISORDERS NITROMED, INC. (US) 2006-05-18 WO disclosed
WO-2006041855-A2 COMPOSITIONS AND METHODS USING APOCYNIN COMPOUNDS AND NITRIC OXIDE DONORS NITROMED, INC. (US) 2006-04-20 WO disclosed
WO-2005107384-A2 METHODS FOR TREATING BLOOD DISORDERS WITH NITRIC OXIDE DONOR COMPOUNDS NITROMED, INC. (US) 2005-11-17 WO disclosed
WO-2005070006-A2 NITROSATED AND/OR NITROSYLATED COMPOUNDS, COMPOSITIONS AND METHODS OF USE NITROMED, INC. (US) 2005-08-04 WO disclosed
WO-2005023183-A2 NITROSATED AD NITROSYLATED DIURETIC COMPOUDS, COMPOSITIONS AND METHODS OF USE NITROMED, INC. (US) 2005-03-17 WO disclosed
WO-2005023182-A2 NITROSATED AND NITROSYLATED CARDIOVASCULAR COMPOUNDS, COMPOSITIONS AND METHODS OF USE NITROMED, INC. (US) 2005-03-17 WO disclosed
WO-2005018561-A2 NITROSATED AND NITROSYLATED CARDIOVASCULAR COMPOUNDS, COMPOSITIONS AND METHODS OF USE NITROMED, INC. (US) 2005-03-03 WO disclosed