Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 9/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 9/20 | 0.41 |
| ▸ | LCK | P06239 | 9/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | INSR | P06213 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | TEC | P42680 | 1/20 | 0.41 |
| ▸ | TXK | P42681 | 1/20 | 0.41 |
| ▸ | BMX | P51813 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2370459 | 1.00 | ITK (0.46) | ITKAURKBLCKLRRK2IRAK4 | |
| SCHEMBL2397090 | 0.88 | ITK (0.47) | ITKAURKBLCKLRRK2IRAK4 | |
| SCHEMBL2397085 | 0.88 | ITK (0.47) | ITKAURKBLCKLRRK2IRAK4 | |
| SCHEMBL2395763 | 0.84 | ITK (0.49) | ITKAURKBLCKLRRK2IRAK4 | |
| SCHEMBL2399117 | 0.84 | ITK (0.49) | ITKAURKBLCKLRRK2IRAK4 | |
| SCHEMBL2395751 | 0.84 | ITK (0.49) | ITKAURKBLCKLRRK2IRAK4 | |
| SCHEMBL2399126 | 0.84 | ITK (0.49) | ITKAURKBLCKLRRK2IRAK4 | |
| SCHEMBL2395129 | 0.83 | ITK (0.51) | ITKAURKBLCKLRRK2IRAK4 | |
| SCHEMBL2395149 | 0.83 | ITK (0.51) | ITKAURKBLCKLRRK2IRAK4 | |
| SCHEMBL2371003 | 0.83 | ITK (0.47) | ITKAURKBLCKLRRK2IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011110575-A1 | DERIVATIVES OF 2-[2-(BENZO- OR PYRIDO-) THIAZOLYLAMINO]-6-AMINOPYRIDINE, USEFUL IN THE TREATMENT OF RESPIRATORIC, ALLERGIC OR INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2011-09-15 | — | — | WO | disclosed |