Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.47 |
| ▸ | CTSD | P07339 | 9/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2370976 | 0.86 | BACE1 (0.58) | BACE1CTSDKCNH2 | |
| SCHEMBL2371411 | 0.80 | BACE1 (0.49) | BACE1CTSDKCNH2 | |
| SCHEMBL2525174 | 0.80 | BACE1 (0.43) | BACE1CTSDKCNH2 | |
| SCHEMBL2522242 | 0.79 | BACE1 (0.51) | BACE1CTSDKCNH2 | |
| SCHEMBL2526437 | 0.78 | BACE1 (0.42) | BACE1CTSDKCNH2 | |
| SCHEMBL2522170 | 0.78 | BACE1 (0.39) | BACE1CTSDKCNH2 | |
| SCHEMBL3280697 | 0.77 | BACE1 (0.53) | BACE1CTSDKCNH2 | |
| SCHEMBL2521701 | 0.75 | BACE1 (0.60) | BACE1CTSD | |
| SCHEMBL2521708 | 0.75 | BACE1 (0.60) | BACE1CTSD | |
| SCHEMBL2521136 | 0.74 | BACE1 (0.73) | BACE1CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011115928-A1 | AMINO -DIHYDROOXAZINE AND AMINO - DIHYDROTHIAZINE SPIRO COMPOUNDS AS BETA - SECRETASE MODULATORS AND THEIR MEDICAL USE | AMGEN INC. (US) | 2011-09-22 | — | — | WO | claimed |
| WO-2011115928-A1 | AMINO -DIHYDROOXAZINE AND AMINO - DIHYDROTHIAZINE SPIRO COMPOUNDS AS BETA - SECRETASE MODULATORS AND THEIR MEDICAL USE | AMGEN INC. (US) | 2011-09-22 | — | — | WO | disclosed |