Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15717058 | 1.00 | BACE1 (0.53) | BACE1CTSD | |
| SCHEMBL15717545 | 0.90 | BACE1 (0.42) | BACE1CTSD | |
| SCHEMBL15716789 | 0.83 | BACE1 (0.38) | BACE1CTSD | |
| SCHEMBL14808465 | 0.82 | BACE1 (0.55) | BACE1CTSD | |
| SCHEMBL2370557 | 0.82 | BACE1 (0.55) | BACE1CTSD | |
| SCHEMBL2370748 | 0.81 | BACE1 (0.37) | BACE1 | |
| SCHEMBL15716845 | 0.81 | BACE1 (0.37) | BACE1CTSD | |
| SCHEMBL14808447 | 0.81 | BACE1 (0.37) | BACE1CTSD | |
| SCHEMBL14808385 | 0.81 | BACE1 (0.37) | BACE1CTSD | |
| SCHEMBL2522579 | 0.77 | BACE1 (0.63) | BACE1CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014078314-A1 | AMINO-OXAZINE AND AMINO-DIHYDROTHIAZINE COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2014-05-22 | — | — | WO | disclosed |
| EP-2547686-A1 | AMINO -DIHYDROOXAZINE AND AMINO - DIHYDROTHIAZINE SPIRO COMPOUNDS AS BETA - SECRETASE MODULATORS AND THEIR MEDICAL USE | Amgen Inc. (US) | 2013-01-23 | — | — | EP | disclosed |
| WO-2011115928-A1 | AMINO -DIHYDROOXAZINE AND AMINO - DIHYDROTHIAZINE SPIRO COMPOUNDS AS BETA - SECRETASE MODULATORS AND THEIR MEDICAL USE | AMGEN INC. (US) | 2011-09-22 | — | — | WO | disclosed |