Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2523497 | 0.82 | BACE1 (0.39) | BACE1 | |
| SCHEMBL14629846 | 0.81 | BACE1 (0.37) | BACE1 | |
| SCHEMBL2370933 | 0.80 | BACE1 (0.35) | BACE1 | |
| SCHEMBL2370552 | 0.72 | MAPT (0.39) | BACE1 | |
| SCHEMBL2371927 | 0.69 | BACE1 (0.35) | BACE1 | |
| SCHEMBL14807845 | 0.68 | BACE1 (0.37) | BACE1 | |
| SCHEMBL2370435 | 0.68 | BACE1 (0.37) | BACE1 | |
| SCHEMBL2370748 | 0.68 | BACE1 (0.37) | BACE1 | |
| SCHEMBL2371084 | 0.68 | BACE1 (0.37) | BACE1 | |
| SCHEMBL14808102 | 0.68 | BACE1 (0.37) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011115928-A1 | AMINO -DIHYDROOXAZINE AND AMINO - DIHYDROTHIAZINE SPIRO COMPOUNDS AS BETA - SECRETASE MODULATORS AND THEIR MEDICAL USE | AMGEN INC. (US) | 2011-09-22 | — | — | WO | disclosed |