Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 16/20 | 0.36 |
| ▸ | CTSD | P07339 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.32 |
| ▸ | CTSB | P07858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2519950 | 0.81 | BACE1 (0.48) | BACE1CTSDKCNH2CTSB | |
| SCHEMBL2518831 | 0.80 | BACE1 (0.55) | BACE1CTSDKCNH2CTSB | |
| SCHEMBL14629825 | 0.79 | BACE1 (0.31) | BACE1CTSD | |
| SCHEMBL2518932 | 0.78 | BACE1 (0.36) | BACE1CTSDKCNH2CTSB | |
| SCHEMBL2525174 | 0.77 | BACE1 (0.43) | BACE1CTSDKCNH2CTSB | |
| SCHEMBL2522252 | 0.77 | BACE1 (0.36) | BACE1CTSDKCNH2 | |
| SCHEMBL2517653 | 0.77 | BACE1 (0.56) | BACE1CTSDKCNH2CTSB | |
| SCHEMBL2382582 | 0.74 | AHR (0.37) | BACE1CTSD | |
| SCHEMBL2522345 | 0.73 | BACE1 (0.33) | BACE1 | |
| SCHEMBL2524174 | 0.72 | BACE1 (0.36) | BACE1CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2547685-A1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETA - SECRETASE MODULATORS | Amgen Inc. (US) | 2013-01-23 | — | — | EP | disclosed |
| WO-2011115938-A1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETA - SECRETASE MODULATORS | AMGEN INC. (US) | 2011-09-22 | — | — | WO | disclosed |