Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 7/20 | 0.78 |
| ▸ | SLC10A2 | Q12908 | 2/20 | 0.71 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.71 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.71 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.71 |
| ▸ | MAPT | P10636 | 2/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | USP2 | O75604 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.65 |
| ▸ | VDR | P11473 | 1/20 | 0.63 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.63 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.61 |
| ▸ | CA1 | P00915 | 5/20 | 0.59 |
| ▸ | CA2 | P00918 | 5/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | CASP7 | P55210 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26425322 | 0.91 | GPBAR1 (0.76) | GPBAR1SLC10A2TBXA2RPDE3ANR1H4 | |
| Glycodeoxycholate SCHEMBL13851639 | 0.88 | GPBAR1 (1.00) | GPBAR1SLC10A2TBXA2RPDE3ANR1H4 | |
| Glycodeoxycholate SCHEMBL20955852 | 0.88 | GPBAR1 (1.00) | GPBAR1SLC10A2TBXA2RPDE3ANR1H4 | |
| Glycodeoxycholate SCHEMBL1218231 | 0.88 | GPBAR1 (1.00) | GPBAR1SLC10A2TBXA2RPDE3ANR1H4 | |
| Glycodeoxycholate SCHEMBL23704979 | 0.88 | GPBAR1 (1.00) | GPBAR1SLC10A2TBXA2RPDE3ANR1H4 | |
| Glycodeoxycholate SCHEMBL24841 | 0.88 | GPBAR1 (1.00) | GPBAR1SLC10A2TBXA2RPDE3ANR1H4 | |
| Glycodeoxycholate SCHEMBL23704978 | 0.88 | GPBAR1 (1.00) | GPBAR1SLC10A2TBXA2RPDE3ANR1H4 | |
| Glycodeoxycholate SCHEMBL23710381 | 0.88 | GPBAR1 (1.00) | GPBAR1SLC10A2TBXA2RPDE3ANR1H4 | |
| Glycodeoxycholate SCHEMBL4301 | 0.88 | GPBAR1 (1.00) | GPBAR1SLC10A2TBXA2RPDE3ANR1H4 | |
| Glycodeoxycholate SCHEMBL26088647 | 0.88 | GPBAR1 (1.00) | GPBAR1SLC10A2TBXA2RPDE3ANR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021155167-A1 | BILE ACID-GCPII INHIBITOR CONJUGATES TO TREAT INFLAMMATORY DISEASES | THE JOHNS HOPKINS UNIVERSITY (US) | 2021-08-05 | — | — | WO | disclosed |