Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A | Q14432 | 1/20 | 0.56 |
| ▸ | HPRT1 | P00492 | 16/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | VCP | P55072 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10554977 | 0.89 | PNP (0.60) | PDE3AHPRT1MEN1KMT2AALDH1A1 | |
| SCHEMBL10481456 | 0.89 | PNP (0.60) | PDE3AHPRT1MEN1KMT2AALDH1A1 | |
| SCHEMBL7749536 | 0.88 | HPRT1 (0.67) | PDE3AHPRT1MEN1KMT2AALDH1A1 | |
| SCHEMBL9583727 | 0.86 | BLM (0.72) | PDE3AHPRT1MEN1KMT2AALDH1A1 | |
| SCHEMBL23352541 | 0.86 | HPRT1 (0.52) | PDE3AHPRT1MEN1KMT2AALDH1A1 | |
| SCHEMBL7749497 | 0.85 | HPRT1 (0.60) | PDE3AHPRT1MEN1KMT2AALDH1A1 | |
| SCHEMBL8839866 | 0.83 | HPRT1 (0.58) | PDE3AHPRT1MEN1KMT2AALDH1A1 | |
| SCHEMBL13127503 | 0.83 | HPRT1 (0.58) | PDE3AHPRT1MEN1KMT2AALDH1A1 | |
| SCHEMBL10436186 | 0.83 | MEN1 (0.68) | PDE3AHPRT1MEN1KMT2AALDH1A1 | |
| SCHEMBL21162677 | 0.83 | PDE3A (0.55) | PDE3AHPRT1MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220290145-A1 | Modified RNA Agents with Reduced Off-Target Effect | ALNYLAM PHARMACEUTICALS, INC. (US) | 2022-09-15 | — | — | US | disclosed |
| US-20210238595-A1 | MODIFIED RNA AGENTS WITH REDUCED OFF-TARGET EFFECT | ALNYLAM PHARMACEUTICALS, INC. (US) | 2021-08-05 | — | — | US | disclosed |