Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 17/20 | 0.34 |
| ▸ | CTSD | P07339 | 5/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.31 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2370642 | 0.85 | BACE1 (0.47) | BACE1CTSDKCNH2 | |
| SCHEMBL2371275 | 0.84 | BACE1 (0.37) | BACE1 | |
| SCHEMBL2371042 | 0.81 | BACE1 (0.45) | BACE1CTSDKCNH2 | |
| SCHEMBL2370421 | 0.77 | BACE1 (0.50) | BACE1CTSDKCNH2 | |
| SCHEMBL2371026 | 0.75 | BACE1 (0.43) | BACE1CTSDKCNH2 | |
| SCHEMBL2370314 | 0.74 | BACE1 (0.35) | BACE1 | |
| SCHEMBL2370445 | 0.74 | BACE1 (0.36) | BACE1CTSD | |
| SCHEMBL2524230 | 0.72 | BACE1 (0.53) | BACE1CTSDKCNH2 | |
| SCHEMBL2524233 | 0.72 | BACE1 (0.53) | BACE1CTSDKCNH2 | |
| SCHEMBL2370545 | 0.72 | BACE1 (0.47) | BACE1CTSDKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2547686-A1 | AMINO -DIHYDROOXAZINE AND AMINO - DIHYDROTHIAZINE SPIRO COMPOUNDS AS BETA - SECRETASE MODULATORS AND THEIR MEDICAL USE | Amgen Inc. (US) | 2013-01-23 | — | — | EP | disclosed |
| WO-2011115928-A1 | AMINO -DIHYDROOXAZINE AND AMINO - DIHYDROTHIAZINE SPIRO COMPOUNDS AS BETA - SECRETASE MODULATORS AND THEIR MEDICAL USE | AMGEN INC. (US) | 2011-09-22 | — | — | WO | disclosed |