Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.65 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.65 |
| ▸ | CTSD | P07339 | 2/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2371282 | 0.90 | BACE1 (0.52) | BACE1BACE2CTSDKCNH2 | |
| SCHEMBL2371790 | 0.83 | BACE1 (0.59) | BACE1BACE2CTSDKCNH2 | |
| SCHEMBL2371087 | 0.82 | BACE1 (0.45) | BACE1BACE2CTSDKCNH2 | |
| SCHEMBL2370318 | 0.82 | BACE1 (0.45) | BACE1BACE2CTSDKCNH2 | |
| SCHEMBL2370594 | 0.82 | BACE1 (0.45) | BACE1BACE2CTSDKCNH2 | |
| SCHEMBL2371562 | 0.82 | BACE1 (0.72) | BACE1BACE2CTSDKCNH2 | |
| SCHEMBL2370018 | 0.79 | BACE1 (0.62) | BACE1BACE2CTSDKCNH2 | |
| SCHEMBL6845643 | 0.79 | BACE1 (0.78) | BACE1BACE2CTSDKCNH2 | |
| SCHEMBL1998429 | 0.79 | BACE1 (1.00) | BACE1BACE2CTSDKCNH2 | |
| SCHEMBL1998426 | 0.79 | BACE1 (1.00) | BACE1BACE2CTSDKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2547686-A1 | AMINO -DIHYDROOXAZINE AND AMINO - DIHYDROTHIAZINE SPIRO COMPOUNDS AS BETA - SECRETASE MODULATORS AND THEIR MEDICAL USE | Amgen Inc. (US) | 2013-01-23 | — | — | EP | disclosed |
| WO-2011115928-A1 | AMINO -DIHYDROOXAZINE AND AMINO - DIHYDROTHIAZINE SPIRO COMPOUNDS AS BETA - SECRETASE MODULATORS AND THEIR MEDICAL USE | AMGEN INC. (US) | 2011-09-22 | — | — | WO | disclosed |