Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 14/20 | 0.43 |
| ▸ | CTSD | P07339 | 4/20 | 0.43 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2522218 | 0.91 | BACE1 (0.39) | BACE1CTSDBACE2KCNH2 | |
| SCHEMBL2522217 | 0.91 | BACE1 (0.39) | BACE1CTSDBACE2KCNH2 | |
| SCHEMBL2371089 | 0.88 | BACE1 (0.47) | BACE1CTSDBACE2KCNH2 | |
| SCHEMBL2371507 | 0.82 | BACE1 (0.42) | BACE1CTSD | |
| SCHEMBL2519147 | 0.81 | BACE1 (0.43) | BACE1CTSDBACE2KCNH2 | |
| SCHEMBL2519146 | 0.81 | BACE1 (0.43) | BACE1CTSDBACE2KCNH2 | |
| SCHEMBL2370597 | 0.74 | BACE1 (0.53) | BACE1CTSDBACE2KCNH2 | |
| SCHEMBL2370592 | 0.74 | BACE1 (0.53) | BACE1CTSDBACE2KCNH2 | |
| SCHEMBL2371423 | 0.74 | BACE1 (0.63) | BACE1CTSDBACE2KCNH2 | |
| SCHEMBL2371426 | 0.74 | BACE1 (0.63) | BACE1CTSDBACE2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2547685-A1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETA - SECRETASE MODULATORS | Amgen Inc. (US) | 2013-01-23 | — | — | EP | disclosed |
| WO-2011115938-A1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETA - SECRETASE MODULATORS | AMGEN INC. (US) | 2011-09-22 | — | — | WO | disclosed |