Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.63 |
| ▸ | RAB9A | P51151 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.54 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.48 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.47 |
| ▸ | TACR1 | P25103 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.43 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29182112 | 0.86 | NPC1 (0.67) | NPC1RAB9ASMN1; SMN2EPHX2GAA | |
| SCHEMBL6830393 | 0.83 | MEN1 (0.53) | NPC1RAB9ASMN1; SMN2GAALMNA | |
| SCHEMBL27560649 | 0.81 | SMN1; SMN2 (0.59) | NPC1RAB9ASMN1; SMN2EPHX2GAA | |
| SCHEMBL31530566 | 0.80 | NPC1 (0.73) | NPC1RAB9ASMN1; SMN2EPHX2GAA | |
| SCHEMBL4982059 | 0.79 | NPC1 (0.67) | NPC1RAB9ASMN1; SMN2EPHX2GAA | |
| SCHEMBL27734524 | 0.79 | NPC1 (0.57) | NPC1RAB9ASMN1; SMN2EPHX2GAA | |
| SCHEMBL8231488 | 0.79 | NPC1 (0.57) | NPC1RAB9ASMN1; SMN2EPHX2GAA | |
| SCHEMBL21523029 | 0.79 | NPC1 (0.67) | NPC1RAB9ASMN1; SMN2EPHX2GAA | |
| Hydrochloric Acid SCHEMBL5405392 | 0.78 | NPC1 (0.65) | NPC1RAB9ASMN1; SMN2EPHX2GAA | |
| SCHEMBL3224949 | 0.77 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2EPHX2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3209732-B1 | SPHINGOSINE-1-PHOSPATE RECEPTOR MODULATORS FOR TREATMENT OF CARDIOPULMONARY DISORDERS | SCRIPPS RESEARCH INST (US) | 2021-08-04 | — | — | EP | disclosed |