⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23219782 | 0.80 | — | — | |
| SCHEMBL26465596 | 0.76 | — | — | |
| SCHEMBL10589136 | 0.76 | — | — | |
| SCHEMBL9921963 | 0.74 | — | — | |
| SCHEMBL18598443 | 0.74 | KDM4E (0.35) | — | |
| SCHEMBL23367126 | 0.72 | — | — | |
| SCHEMBL19592247 | 0.71 | — | — | |
| SCHEMBL12060382 | 0.66 | — | — | |
| SCHEMBL23395247 | 0.66 | KDM4E (0.31) | — | |
| SCHEMBL6561568 | 0.66 | TSHR (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11566015-B2 | Melanocortin subtype-2 receptor (MC2R) antagonists and uses thereof | Crinetics Pharmaceuticals, Inc. (US) | 2023-01-31 | — | — | US | disclosed |
| US-20210238164-A1 | MELANOCORTIN SUBTYPE-2 RECEPTOR (MC2R) ANTAGONISTS AND USES THEREOF | Crinetics Pharmaceuticals, Inc. | 2021-08-05 | — | — | US | disclosed |