Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 7/20 | 0.59 |
| ▸ | CBLB | Q13191 | 9/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.42 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MYLK | Q15746 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL943454 | 0.96 | MAP3K5 (0.63) | MAP3K5CBLBLMNAGAACD274 | |
| SCHEMBL14482051 | 0.90 | MAP3K5 (0.63) | MAP3K5CBLBLMNAGAACD274 | |
| SCHEMBL947146 | 0.87 | MAP3K5 (0.62) | MAP3K5CBLBLMNAGAACD274 | |
| SCHEMBL943352 | 0.86 | MAP3K5 (0.60) | MAP3K5CBLBLMNAGAACD274 | |
| SCHEMBL943911 | 0.86 | MAP3K5 (0.61) | MAP3K5CBLBLMNAGAAMYLK | |
| SCHEMBL944324 | 0.85 | MAP3K5 (0.60) | MAP3K5CBLBLMNAGAACD274 | |
| SCHEMBL1082642 | 0.85 | MAP3K5 (0.60) | MAP3K5CBLBLMNAGAACD274 | |
| SCHEMBL1082758 | 0.84 | MAP3K5 (0.68) | MAP3K5CBLBLMNAGAACD274 | |
| SCHEMBL945365 | 0.84 | MAP3K5 (0.61) | MAP3K5CBLBLMNAGAAMYLK | |
| SCHEMBL943988 | 0.84 | MAP3K5 (0.69) | MAP3K5CBLBLMNAGAACLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3858824-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | Gilead Sciences, Inc. (US) | 2021-08-04 | — | — | EP | disclosed |