Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 13/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 7/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 12/20 | 0.44 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.35 |
| ▸ | TRPC7 | Q9HCX4 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23722317 | 0.91 | HRH1 (0.45) | HRH1CHRM1KCNH2ADRA2AHTR2B | |
| SCHEMBL23722293 | 0.90 | HRH1 (0.46) | HRH1CHRM1KCNH2ADRA2AHTR2B | |
| SCHEMBL23722306 | 0.90 | HRH1 (0.44) | HRH1CHRM1KCNH2ADRA2AHTR2B | |
| SCHEMBL23721027 | 0.89 | HRH1 (0.45) | HRH1CHRM1KCNH2ADRA2AHTR2B | |
| SCHEMBL23721290 | 0.89 | HRH1 (0.42) | HRH1CHRM1KCNH2ADRA2AHTR2B | |
| SCHEMBL23721301 | 0.88 | HRH1 (0.44) | HRH1CHRM1KCNH2ADRA2AHTR2B | |
| SCHEMBL23722273 | 0.88 | HRH1 (0.45) | HRH1CHRM1KCNH2ADRA2AHTR2B | |
| SCHEMBL23721268 | 0.88 | HRH1 (0.44) | HRH1CHRM1KCNH2ADRA2AHTR2B | |
| SCHEMBL23721409 | 0.88 | HRH1 (0.44) | HRH1CHRM1KCNH2ADRA2AHTR2B | |
| SCHEMBL12930598 | 0.88 | HRH1 (0.61) | HRH1CHRM1KCNH2ADRA2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445343-B1 | PRODRUGS OF NH-ACIDIC COMPOUNDS | ALKERMES PHARMA IRELAND LTD (IE) | 2021-08-04 | — | — | EP | disclosed |